منابع مشابه
TRPV4 shows TRPP2 the moves
You'd think that something as dramatic as a bending cilia would be easy to sense, especially if your own activity depended on it. But the ion channel TRPP2 is oblivious to the cilia movement that activates it, and depends on another channel to relay the information, Köttgen et al. report. In the kidney, bending of the cilia in response to the fl ow of fl uid through the nephron tubule triggers ...
متن کاملTRPP2 and TRPV4 form a polymodal sensory channel complex
The primary cilium has evolved as a multifunctional cellular compartment that decorates most vertebrate cells. Cilia sense mechanical stimuli in various organs, but the molecular mechanisms that convert the deflection of cilia into intracellular calcium transients have remained elusive. Polycystin-2 (TRPP2), an ion channel mutated in polycystic kidney disease, is required for cilia-mediated cal...
متن کاملOscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development
In vertebrates, heart pumping is required for cardiac morphogenesis and altering myocardial contractility leads to abnormal intracardiac flow forces and valve defects. Among the different mechanical cues generated in the developing heart, oscillatory flow has been proposed to be an essential factor in instructing endocardial cell fate toward valvulogenesis and leads to the expression of klf2a, ...
متن کاملTRPP2 and TRPV4 Form an EGF-Activated Calcium Permeable Channel at the Apical Membrane of Renal Collecting Duct Cells
OBJECTIVE Regulation of apical calcium entry is important for the function of principal cells of the collecting duct. However, the molecular identity and the regulators of the transporter/channel, which is responsible for apical calcium entry and what factors regulate the calcium conduction remain unclear. METHODS AND RESULTS We report that endogenous TRPP2 and TRPV4 assemble to form a 23-pS ...
متن کاملAquaporin clears its own path
You'd think that something as dramatic as a bending cilia would be easy to sense, especially if your own activity depended on it. But the ion channel TRPP2 is oblivious to the cilia movement that activates it, and depends on another channel to relay the information, Köttgen et al. report. In the kidney, bending of the cilia in response to the fl ow of fl uid through the nephron tubule triggers ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1823iti1